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Structural and Functional Characteristics of the Heart in Schoolchildren Living in the North with Controlled Bronchial Asthma. Pp. 17–28.

Версия для печати

Section: Physiology

UDC

[612.17:616.248]-053.5(470.11)

Authors

Gribanov Anatoly Vladimirovich, Institute of Medical and Biological Research, Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russia) 

Kraynova Irina Nikolaevna, Institute of Medical and Biological Research, Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russia)

Abstract

Bronchial asthma (BA) is one of the most common child pathologies in the European North of Russia. Up to date, the cardiovascular system of children with this disease has been poorly investigated, even though it has a close functional relationship with lungs. Patients with mild BA constitute the largest proportion of its incidence and at the same time they are the least examined group. This article studies heart characteristics of schoolchildren living in the north and suffering from BA. The data were obtained using transthoracic echocardiography, taking into account the development stage of the cardiovascular system of each child. We studied the structural and functional parameters of the hearts of children aged 7–17 years born and living in the city of Arkhangelsk. The main group included 148 children with controlled BA (mild, during remission); the control group was comprised of 491 healthy children. We found that the most sensitive to BA factors was the cardiovascular system of boys aged 7–9 years and girls aged 10–13 years with this condition. It is in these groups of children that the largest number of changes in the structural and functional cardiac parameters was observed. It should be noted that the duration of BA between the age groups of boys and girls under study was not significantly different. What is more, neither of the groups showed any signs of pulmonary hypertension, which was determined using transtricuspid regurgitation.

Keywords

schoolchildren, European North of Russia, bronchial asthma, echocardiography, structural and functional characteristics of the heart.
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References

  1. Alieva V.E. Osobennosti immunnogo statusa i tsitokinovogo profilya u detey s bronkhial’noy astmoy [Characteristics of Immune Status and Cytokine Profile in Children with Atopic Bronchial Asthma]. Astma, 2010, vol. 11, no. 2, pp. 100–103. 
  2. Revyakina V.A. Bronkhial’naya astma u detey: prichiny vozniknoveniya [Bronchial Asthma in Children: Causes]. Detskiy doktor, 1999, no. 2, pp. 24–25. 
  3. Szefler S.J. Advances in Pediatric Asthma in 2009: Gaining Control of Childhood Asthma. J. Allergy Clin. Immunol., 2010, vol. 125, no. 1, pp. 69–78. 
  4. Baydakova E.V., Unguryanu T.N., Buzinov R.V., Gudkov A.B. Zabolevaemost’ bronkhial’noy astmoy naseleniya Arkhangel’skoy oblasti [Bronchial Asthma Incidence Among Arkhangelsk Region Population]. Ekologiya cheloveka, 2011, no. 12, pp. 8–13. 
  5. Ovcharenko S.I. Bronkhial’naya astma: diagnostika i lechenie [Asthma: Diagnosis and Treatment]. Russkiy meditsinskiy zhurnal, 2002, vol. 10, no. 17, p. 766. 
  6. Goryachkina L.A., Drobik O.S., Biteeva D.V. Antagonisty leykotrienovykh retseptorov v lechenii bronkhial’noy astmy [Leukotriene Receptor Antagonists in the Treatment of Bronchial Asthma]. Vestnik semeynoy meditsiny, 2010, no. 5–6, pp. 1–4. 
  7. Useynova N.N., Shovkun V.A., Mizernitskiy Yu.L. Immunoendokrinnye mekhanizmy formirovaniya bronkhial’noy astmy u detey rannego vozrasta s povtornymi respiratornymi zabolevaniyami [Immune and Endocrine Mechanisms of Formation of Recurrent Bronchoobstructive Syndrome in Children of Early Age with Repeated Respiratory Diseases]. Astma, 2010, vol. 11, no. 2, pp. 83–87. 
  8. Bronkhial’naya astma u detey. Strategiya lecheniya i profilaktiki. Natsional’naya programma [Bronchial Asthma in Children. The Treatment and Prevention Strategy. National Programme]. 2nd ed. Moscow, 2008. 108 p. 
  9. Grippi M.A. Pulmonary Pathophysiology. Lippincott Williams & Wilkin, 1995. 352 p. (Russ. ed.: Grippi M.A. Patofiziologiya legkikh. Moscow, 1997. 344 p.). 
  10. Lyapunov A.V., Balabolkin I.I., Smirnov I.E. Kliniko-morfologicheskaya kharakteristika vospaleniya dykhatel’nykh putey pri bronkhial’noy astme i ego biologicheskie markery [Clinical and Morphological Characteristics of Airway Inflammation at Asthma and Its Biological Markers]. Pediatriya, 2003, no. 6, pp. 1–5. 
  11. Nezabudkin S.N., Antonova T.I., Rostova A.V. Bronkhial’naya astma i nespetsificheskaya giperreaktivnost’ bronkhov u detey [Bronchial Asthma and Nonspecific Bronchial Hyperreactivity in Children]. Pul’monologiya detskogo vozrasta: problemy i resheniya, 2007, iss. 7, pp. 141–146. 
  12. Chuchalin A.G. Bronkhial’naya astma [Bronchial Asthma]. Moscow, 2001. 144 p. 
  13. Ivanov S.N., Sokolov A.A., Krivonogov N.G. Neinvazivnye metody diagnostiki legochnoy gipertenzii u detey s vrozhdennymi porokami serdtsa [Non-Invasive Methods of Diagnosing Pulmonary Hypertension in Children with Congenital Heart Disease]. Materialy III Vseros. seminara pamyati professora N.A. Belokon’ [Proc. 3rd Russia-Wide Seminar in Memory of Professor N.A. Belokon]. Arkhangelsk, 2003, pp. 76–83. 
  14. Macharadze D.Sh., Dzhishkariani I.R., Beridze V.D. Svyaz’ rasprostranennosti allergicheskikh zabolevaniy s nekotorymi faktorami okruzhayushchey sredy [Relationship Between Prevalence of Allergy and Some Environmental Factors]. Astma, 2006, no. 7, pp. 36–41. 
  15. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Heart, Lung, and Blood Institute, 2007. 
  16. Jackson D.J., Sykes A., Mallia P., Johnston S.L. Asthma Exacerbations: Origin, Effect, and Prevention. J. Allergy Clin. Immunol., 2011, vol. 128, no. 6, pp. 1165–1174. 
  17. Gribanov A.V., Beresnev S.I. Vozrastnye osobennosti tsentral’noy gemodinamiki u shkol’nikov Evropeyskogo Severa [Age-Related Features of Central Haemodynamics in Schoolchildren of the European North]. Sever. Deti. Shkola: sb. nauch. tr. [North. Children. School: Collected Sci. Papers]. Ed. by Gribanov A.V. Arkhangelsk, 1994. Iss. 1, pp. 73–83. 
  18. Gudkov A.B., Shishelova O.V. Morfofunktsional’nye osobennosti serdtsa i magistral’nykh sosudov u detey shkol’nogo vozrasta [Morphofunctional Features of Heart and Great Vessels in School-Age Children]. Arkhangelsk, 2011. 152 p. 
  19. Bezrukova D.A. Atopicheskaya patologiya u detey, prozhivayushchikh v usloviyakh sochetannogo vozdeystviya antropogennoy nagruzki i yodnogo defitsita: avtoref. dis. … d-ra med. nauk [Atopic Diseases in Children Living Under the Combined Effect of Anthropogenic Stress and Iodine Deficiency: Dr. Med. Sci. Diss. Abs.]. Astrakhan, 2010. 43 p. 
  20. Dybunova E.L. Rasprostranennost’ i techenie allergicheskikh zabolevaniy u detey, prozhivayushchikh v razlichnykh ekologo-geograficheskikh usloviyakh [Prevalence and Course of Allergies in Children Living Under Various Ecological and Geographical Conditions]. Pul’monologiya detskogo vozrasta: problemy i resheniya, 2007, iss. 7, pp. 134–136. 
  21. Allergiya u detey: ot teorii – k praktike [Allergy in Children: From Theory to Practice]. Ed. by Namazova- Baranova L.S. Moscow, 2010–2011. 668 p. 
  22. Belyakov A.V., Shishkina M.I. Sostoyanie sistemnoy i legochnoy gemodinamiki i mikrotsirkulyatsii pri bronkhial’noy astme u detey [The State of the Systemic and Pulmonary Haemodynamics and Microcirculation in Children with Bronchial Asthma]. Pediatriya, 2008, no. 4, pp. 30–33. 
  23. Gribanov A.V. Dinamika krovoobrashcheniya u shkol’nikov v usloviyakh Evropeyskogo Severa: avtoref. dis. ... d-ra med. nauk [Haemodynamics in Schoolchildren in the European North: Dr. Med. Sci. Diss. Abs.]. Arkhangelsk, 1991. 38 p. 
  24. Rukovodstvo po klinicheskomu issledovaniyu rebenka [A Guide to the Clinical Examination of a Child]. Ed. by Makarova V.I. Arkhangelsk, 2002. 279 p. 
  25. Starovoytova E.A., Ivanov S.N., Ogorodova L.M. Osobennosti gemodinamiki malogo kruga krovoobrashcheniya i funktsional’nogo sostoyaniya u detey s bronkhial’noy astmoy [Features of Pulmonary Haemodynamics and Endothelium Function in Children with Asthma]. Pul’monologiya, 2007, no. 4, pp. 56–59. 
  26. Asriyants I.E., Kopytov G.A., Kharchev A.V. Otsenka strukturno-funktsional’nykh pokazateley miokarda u detey s bronkhial’noy astmoy [The Structural and Functional Evaluation of Myocardium in Children with Bronchial Asthma]. Allergologiya, 1999, no. 1, pp. 31–35. 
  27. Paleev N.R., Tsar’kova L.N., Chereyskaya N.K. Legochnaya gipertenziya i porazhenie serdtsa pri khronicheskikh nespetsificheskikh zabolevaniyakh legkikh [Pulmonary Hypertension and Heart Disease at Chronic Nonspecific Lung Disease]. Kardiologiya, 1988, no. 12, pp. 58–63. 
  28. Soroka N.D., Orlova N.V. Sovremennye printsipy diagnostiki i lecheniya khronicheskogo legochnogo serdtsa u detey [Current Principles of Diagnosis and Treatment of Chronic Pulmonary Heart Disease in Children]. Pul’monologiya detskogo vozrasta: problemy i resheniya, 2007, iss. 7, pp. 73–84.