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The Relation Between Microflora and Innate Immunity Responses in Mucosa- Associated Lymphoid Tissue. Pp. 71–80.

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Section: Medical and biological sciences

UDC

[616-097-053.1:616.34-008.87]:611.018.1

Authors

Dobrodeeva Liliya Konstantinovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia) 

Samodova Anna Vasilyevna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Patrakeeva Veronika Pavlovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Abstract

The paper evaluates the intensity of innate immunity responses in mucosa-associated lymphoid tissue to changes in the composition of microorganisms inhabiting mucous in healthy people and those with inflamed gut. It shows the age-related dynamics of the content of oncofetal antigens in the blood, with the rise of mucous glycoproteins in patients older than 60 years. We found that mucous glycoproteins accumulate in the blood serum in order to enhance the protective activity of the surface epithelium of the mucous membrane. The content and structure of mucosa-associated lymphoid tissue cells are reinforced by migrating neutrophil granulocytes, monocytes/macrophages, and natural killer cells. The highest activity of phagocytic protection by mucosa-associated lymphoid tissue cells was recorded in the gut, while the lowest phagocytic activity was found in the urinary system (p < 0.01). The exceeded threshold of physiological concentrations of symbionts and their metabolic products causes innate immunity response in the tissue of barrier organs. Further we showed that the levels of phagocytic activity, neutrophilic in particular, depend on microorganism concentrations on the surface of barrier organs and that their increased levels activate neutrophil granulocyte migration from the bloodstream, as well as chemotaxis, adhesion, degranulation, and engulfment. Enhanced secretory activity of neutrophils allows a paracrine community of cells to form in mucosa-associated tissue. In cases where innate immunity fails to cope with pathogenic microflora, this paracrine community initiates the development of specific responses of the adaptive immunity.

Keywords

cytokines, mucosa-associated lymphoid tissue, microflora, granulocytes, monocytes, lymphocytes, phagocytosis, microflora.
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