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The Effect of Vitamin K Antagonists on Thrombinemia and Homocysteine Levels. C. 66-72

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Section: Medical and biological sciences

UDC

615.273.53.03(470.11)

Authors

Rogozina Aleksandra Sergeevna
Postgraduate Student, Northern State Medical University (Arkhangelsk, Russia)
Vorobyeva Nadezhda Aleksandrovna
Northern State Medical University; Northern Branch of the Hematology Research Centre, Russian Academy of Medical Sciences (Arkhangelsk, Russia)

Abstract

Vitamin K antagonists are used to prevent and treat thrombosis, including that in patients with artificial heart valves, atrial fibrillation and thrombosis of various localization. This paper aimed to determine the levels of thrombin–antithrombin, thrombin, and homocysteine in patients with atrial fibrillation and deep vein thrombosis, taking vitamin K antagonists. The study included 46 patients, both men and women, aged 54 years (from 21 to 76 years). The first group of patients had deep vein thrombosis (n=37), the second – atrial fibrillation (n=9). We evaluated the content of thrombin–antithrombin, thrombin, and homocysteine in the blood serum originally (on the first day) and on the 6th month of warfarin therapy. The initial values had no statistically significant differences between the groups, with the exception of thrombin–antithrombin levels, which were higher in patients with deep vein thrombosis (p < 0.05) than those in patients with atrial fibrillation. After a six month’s warfarin therapy, patients with atrial fibrillation showed a decrease in thrombin level (p < 0.05), while the level of thrombin–antithrombin stayed unchanged (p > 0.05). In patients with deep vein thrombosis, the level of thrombin remained the same (p > 0.05) while the level of thrombin-antithrombin was statistically significantly higher (p > 0.05). All patients showed high homocysteine levels, which can be explained by their diet excluding green plants and vegetables, i.e. deficient in folic acid and B vitamins.

Keywords

thrombin, thrombin–antithrombin, homocysteine, warfarin, thrombosis, atrial fibrillation
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