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The Ratio of Blood Levels of Saturated Fatty Acids and Metabolites of Carbohydrate Metabolism in Residents of the Arctic Aged 22–35 Years. P. 44–55

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Section: Physiology

UDC

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Authors

Artem A. Bichkaev*/**, Fatima A. Bichkaeva*, Natal’ya I. Volkova*/**, Tat’yana V. Tret’yakova*, Ol’ga S. Vlasova*, Ekaterina V. Nesterova*, Boris A. Shengof */**, Nina F. Baranova*
*Federal Research Centre for Integrated Studies of the Arctic, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
**Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russian Federation)

Abstract

The study involved 370 adults from the Subarctic (SR) and Arctic (AR) regions of the European North of Russia aged between 22 and 35 years. The parameters of serum carbohydrate metabolism, level of saturated fatty acids (SAFA) and body mass index (BMI) were determined. Using the correlation and variance analysis we identified the dependence of the parameters of carbohydrate metabolism on the concentration of short- (SC), medium- (MC) and long-chain (LC) SAFA in the blood of SR and AR inhabitants. It was proven that in SR residents the prime factor of increasing glucose level is BMI in combination with decanoic and undecylic (C11:0) SC SAFA, tridecanoic (C13:0), myristic and pentadecanoic MC, palmitic (C16:0), heptadecanoic, arachidic and heneicosanoic (C21:0) LC SAFA (10– 15 %), as well as a set of factors BMI×sex×C16:0 and sex×C13:0 (5.0–8.6 %). In AR residents the largest effect on the decrease in glucose level was produced by caprylic, pelargonic and undecylic SC SAFA (15– 21 %), then tridecanoic MC SAFA (11.0 %), and palmitic, heptadecanoic, stearic (C18:0), heneicosanoic, behenic (C22:0) and lignoceric LC SAFA (6.0–11.0 %); the smallest effect was produced by the complex sex×C18:0 (8.0 %). A slight decline in the activity of anaerobic processes in SR residents was caused separately by caproic and heneicosanoic SAFA (9.3–15 %), while in AR residents by caproic, caprylic, pelargonic, pentadecanoic, palmitic, heptadecanoic and lignoceric SAFA (10.4–18.1 %) and complexes BMI×sex×C22:0 (20.0 %), BMI×sex×C21:0, BMI×sex×C12:0, and sex×C11:0 (11–13 %).

Keywords

saturated fatty acids; short-, medium- and long-chain fatty acids; metabolites of carbohydrate metabolism; body mass index; adult residents of the Subarctic region, adult residents of the Arctic region
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