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Significance of the Level of Hypocapnia for Electroencephalographic Changes During Prolonged Hyperventilation in Humans. P. 24–32

Версия для печати

Section: Physiology

UDC

612.1:612.821

Authors

Denis B. Demin*, Liliya V. Poskotinova*
*Federal Center for Integrated Arctic Research, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
Corresponding author: Denis Demin, address: prosp. Lomonosova 249, Arkhangelsk, 163000, Russian Federation;
e-mail: denisdemin@mail.ru

Abstract

The paper studied the changes in electroencephalographic parameters during prolonged voluntary hyperventilation in 30 healthy men aged 18–20 years. Continuous monitoring of blood gases (carbon dioxide and oxygen) and oxygen saturation was performed using the Radiometer Medical TCM40 transcutaneous monitoring system. Electroencephalograms (EEG) were recorded unipolarly in 16 standard leads during each stage of the study using EEGA-21/26 Encephalan-131-03 EEG analyser; the subjects were in a state of quiet wakefulness with their eyes closed. Having recorded the initial values of the parameters under study, we performed cyclic hyperventilation, during which the external respiration rate increased on the average by a factor of 4 to 5: at the first stage, until the transcutaneous carbon dioxide tension reached 25 mm Hg, and then, after rest and recovery, at the second stage of hyperventilation, until it reached 15 mm Hg. We show that the detected EEG changes during prolonged hyperventilation directly depend on the level of transcutaneous carbon dioxide tension. Hypocapnia with carbon dioxide level of 15 mm Hg caused a more pronounced increase in both intracortical and deep limbic-reticular activity of the brain, manifested in an increase in all types of EEG activity; moreover, in more than 70 % of cases we saw generalized paroxysmal activity. The initial EEG pattern after the end of hyperventilation was restored long before the recovery of carbon dioxide tension specific to each subject. The parameters of oxygen saturation continued to decrease even after the test, which can be a factor of delayed hypoxia in response to prolonged hyperventilation.

Keywords

hyperventilation, cyclic respiration, electroencephalogram, hypocapnia, hypoxia
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References

  1. Gudkov A.B., Popova O.N. Vneshnee dykhanie cheloveka na Evropeyskom Severe [External Respiration of Humans in the European North]. Arkhangelsk, 2009. 293 p. 
  2. Pushkina V.N., Gribanov A.V. Sezonnye izmeneniya vzaimootnosheniy pokazateley kardiorespiratornoy sistemy u yunoshey v usloviyakh tsirkumpolyarnogo regiona [Seasonal Changes of Interrelations Between Cardiorespiratory System Characteristics of Youths in Conditions of Circumpolar Region]. Ekologiya cheloveka, 2012, no. 9, pp. 26–31. 
  3. Smirnov A.G., Korsakova E.A. Kharakter izmeneniy EEG cheloveka pri dlitel’noy giperventilyatsii [Changes in EEG Induced by Prolonged Hyperventilation in Humans]. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova, 1997, vol. 83, no. 11–12, pp. 64–73. 
  4. Terekhin P.I. Rol’ gipokapnii v mekhanizmakh indutsirovaniya izmenennykh sostoyaniy soznaniya [Role of Hypocapnia in the Mechanisms of Induction of Altered States of Consciousness]. Fiziologiya cheloveka, 1996, vol. 22, no. 6, pp. 100–105. 
  5. Burykh E.A. Vzaimootnosheniya gipokapnii, gipoksii, mozgovogo krovotoka i elektricheskoy aktivnosti mozga pri proizvol’noy giperventilyatsii u cheloveka [Interrelations of Hypocapnia, Hypoxia, Cerebral Blood Flow and Electrical Activity of the Brain Under Voluntary Hyperventilation in Humans]. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova, 2007, vol. 93, no. 9, pp. 982–1000. 
  6. Ma X., Bay-Hansen R., Hauerberg J., Knudsen G.M., Olsen N.V., Juhler M. Effect of Graded Hyperventilation on Cerebral Metabolism in a Cisterna Magna Blood Injection Model of Subarachnoid Hemorrhage in Rats. J. Neursurg. Anesthesiol., 2006, vol. 18, no. 1, pp. 18–23. 
  7. Poskotinova L.V., Kamenchenko E.A. Pokazateli reoentsefalogrammy pokoya u zdorovykh podrostkov 15–17 let na Evropeyskom Severe [Quiet Rheoencephalogram Indicators in Healthy Adolescents Aged 15–17 Years in European North]. Ekologiya cheloveka, 2011, no. 9, pp. 36–44. 
  8. Spelten O., Fiedler F., Schier R., Wetsch W.A., Hinkelbein J. Transcutaneous PtcCO2 Measurement in Combination with Arterial Blood Gas Analysis Provides Superior Accuracy and Reliability in ICU Patients. J. Clin. Monit. Comput., 2017, vol. 31, no. 1, pp. 153–158. 
  9. Breslav I.S., Nozdrachev A.D. Regulyatsiya dykhaniya: vistseral’naya i povedencheskaya sostavlyayushchie [Regulation of Respiration: Visceral and Behavioural Components]. Uspekhi fiziologicheskikh nauk, 2007, vol. 38, no. 2, pp. 26–45. 
  10. Rodshtat I.V. Metaforicheskoe fiziologicheskoe (psikhofiziologicheskoe) ponimanie soznaniya [Metaphoric Physiological (Psycho-Physiological) Understanding of Consciousness]. Vestnik novykh meditsinskikh tekhnologiy, 2000, vol. 7, no. 2, pp. 156–158. 
  11. Kozlov V.V. Psikhotekhnologii izmenennykh sostoyaniy soznaniya [Psychotechnologies of Altered States of Consciousness]. Moscow, 2005. 544 p. 
  12. Sviderskaya N.E., Bykov P.V. Spatial Organization of EEG Activity During Active Hyperventilation (Cyclic Breath) I. General Patterns of Changes in Brain Functional State and the Effect of Paroxysmal Activity. Hum. Physiol., 2006, vol. 32, no. 2, pp. 140–149. 
  13. Wolff H.G., Lennox W.G. Cerebral Circulation. XII. The Effect on Pial Vessels of Variations in the Oxygen and Carbon Dioxide Content of the Blood. Arch. Neurol. Psychiatry, 1930, vol. 23, pp. 1097–1120. 
  14. McKay L.C., Evans K.C., Frackowiak R.S.J., Corfield D.R. Neural Correlates of Voluntary Breathing in Humans. J. Appl. Physiol., 2003, vol. 95, no. 3, pp. 1170–1178.