UDC

612.89+612.63+612.17

Authors

Andrey N. Trukhin*, Aleksey A. Kunshin*
*Vyatka State University (Kirov, Russian Federation)
Corresponding author: Andrey Trukhin, address: 36 Moskovskaya St., Kirov, 610000, Russian Federation; е-mail: trukhinandrey@rambler.ru

Abstract

This paper summarizes the available data in scientific literature (mainly obtained in the Laboratory of Muscle and Bioactive Substance Physiology, Vyatka State University) indicating the presence in human urine and serum of the endogenous blocker and endogenous sensitizer of M-cholinergic receptors (EBMChR and ESMChR). Part 2 of this survey reports on the ability of blood serum (in certain dilutions), due to the presence of EBMChR, to nonselectively reduce activation efficiency of M-cholinergic receptors (M-ChR), including M1-, M2-, M3- and M4-ChR of smooth muscles of uterus, blood vessels, trachea and myocardium. In addition to EBMChR, blood serum contains ESMChR, which increases the efficiency of M-ChR cell activation. It is quite possible that EBMChR includes lysophosphatidylcholine (LPC), while ESMChR includes such components as LPC and phosphatidylcholine (PC). The likelihood of EBMChR and ESMChR activity manifestation in the blood serum depends on its dilution factor (for EBMChR activity this likelihood is higher at 1:10, 1:50, and 1:100, while for ESMChR activity, at 1:500, 1:10³ and 1:10⁴ dilution). It is shown here that the effect of EBMChR is long-term (up to 100 minutes) at continuous exposure of the test object to blood serum. At present, data on ESMChR is scarce. However, in general, it can be argued that EBMChR and, probably, even ESMСhR play an important role in humans and animals also as components of the humoral arm of the autonomic nervous system, which also includes endogenous modulators of activation efficiency of beta- and alpha-adrenergic receptors (AR), in particular, endogenous sensitizers of beta- and alpha-AR and endogenous blockers of betaand alpha-AR.

Keywords

endogenous modulators of M-cholinergic receptors, endogenous modulators of alpha- and beta-adrenergic receptors, autonomic nervous system

References

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