Legal and postal addresses of the publisher: office 1410a, 17 Naberezhnaya Severnoy Dviny, Arkhangelsk, 163002, Russian Federation, Northern (Arctic) Federal University named after M.V. Lomonosov

Phone: (818-2) 21-61-21
E-mail: vestnik_med@narfu.ru
http://medbio.narfu.ru/en/

ABOUT JOURNAL

Key Features of Functional Maturity of the Cerebral Cortex in Children with Multiple Risk Factors During Early Development. P. 14–24

Версия для печати

Section: Physiology

UDC

612.821–53.5+618.3

Authors

Elena V. Kazakova*, Lyudmila V. Sokolova*
*Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russian Federation)

Abstract

This research deals with functional maturity of the cerebral cortex in children aged 7–8 years with dysontogenetic risk factors during the preschool period. The paper analysed the parameters of brain maturity and the medical history of 41 first formers. The summarized data of the parents’ and teachers’ questionnaires aiming to reveal peculiarities of child development in the preschool period allowed us to identify groups of first formers with multiple risk factors and without risk factors in their early development. Electroencephalograms were recorded in the state of quiet wakefulness and at functional loads (photostimulation and hyperventilation). Functional maturity of the cerebral cortex was evaluated using the EEG-ekspert computer-aided diagnostic system. The qualitative analysis of the children’s electroencephalograms showed differences in the development of rhythmogenic structures of the cerebral cortex. In schoolchildren with multiple risk factors, the nature of the alpha rhythm (in 65.0 % of the children) and its changes at the functional tests deviated from the age norm. The mean values of all cortical maturity parameters in each group were lower, which can indicate lagging functional maturation of the cerebral cortex. Parameters of immature basic background EEG rhythm are a risk marker for difficulties with learning or socialization at various stages of a child’s development. EEG tests at the early stages of ontogenesis allow us to take timely measures in order to minimize potential deviations in child development.

Keywords

brain functional maturity, electroencephalogram, risk factors in early development, dysontogenesis, primary school children
Download (pdf, 1.8MB )

References

  1. Bezrukikh M.M., Machinskaya R.I., Sugrobova G.A. Differentsirovannoe vliyanie funktsional’noy zrelosti kory i regulyatornykh struktur mozga na pokazateli poznavatel’noy deyatel’nosti u detey 7-8 let [Differential Effect of Functional Maturity of the Cortex and Regulatory Brain Structures on Cognitive Activity in Children Aged 7–8 years]. Fiziologiya cheloveka, 1999, vol. 25, no. 5, pp. 14–21. 
  2. Kozhushko N.Yu., Ponomarev V.A., Matveev Yu.K., Evdokimov S.A. Developmental Features of the Formation of the Brain’s Bioelectrical Activity in Children with Remote Consequences of a Perinatal Lesion of the CNS: II. EEG Typology in Health and Mental Disorders. Human Physiology, 2011, vol. 37, no. 3, pp. 271–277. 
  3. Partsalis E.M. Faktory riska narusheniya kognitivnogo razvitiya u detey (obzor) [Risk Factors of Violation of Cognitive Development in Children]. Novye issledovaniya, 2013, no. 2, pp. 4–22. 
  4. Sokolova L.V., Kazakova E.V. Vliyanie faktorov riska rannego dizontogeneza na funktsional’nuyu zrelost’ kory bol’shikh polushariy golovnogo mozga u detey-severyan [Influence of Risk Factors of Early Dysontogenesis on Functional Maturity of Cerebral Cortex in Children Living in the North]. Rebenok v usloviyakh Evropeyskogo Severa. Morfofunktsional’nyy status [A Child in the European North. Morphofunctional Status]. Saarbrücken, 2011, pp. 112–125. 
  5. Touwen B.C., Hadders-Algra M., Huisjes H.J. Hypotonia at Six Years in Prematurely-Born or Small-for- Gestational-Age Children. Early Hum. Dev., 1988, vol. 17, no. 1, pp. 79–88. 
  6. Machinskaya R.I., Lukashevich I.P., Fishman M.N. Dinamika elektricheskoy aktivnosti mozga u detey 5-8-letnego vozrasta v norme i pri trudnostyakh obucheniya [Dynamics of Brain Electric Activity in Healthy Children Aged 5–8 Years and Their Peers with Learning Disabilities]. Fiziologiya cheloveka, 1997, vol. 23, no. 5, pp. 5–11. 
  7. Farber D.A., Beteleva T.G., Gorev A.S., Dubrovinskaya N.V., Machinskaya R.I. Funktsional’naya organizatsiya razvivayushchegosya mozga v formirovanii kognitivnoy deyatel’nosti [Functional Organization of the Developing Brain in the Formation of Cognitive Activity]. Bezrukikh M.M., Farber D.A. (eds.). Fiziologiya razvitiya rebenka: teoreticheskie i prikladnye aspekty [Physiology of Child Development: Theoretical and Applied Aspects]. Moscow, 2000, pp. 82–105. 
  8. Lukashevich I.P., Machinskaya R.I., Fishman M.N. Avtomatizirovannaya diagnosticheskaya sistema “EEGekspert” [EEG-Expert Automated Diagnostic System]. Meditsinskaya tekhnika, 1999, no. 6, pp. 29–34. 
  9. Lukashevich I.P., Fishman M.N., Machinskaya R.I. Issledovanie neyrofiziologicheskikh mekhanizmov zaderzhki psikhicheskogo razvitiya u detey. Strukturnyy analiz EEG [Study of Neurophysiological Mechanisms of Mental Retardation in Children. Structural EEG Analysis]. Fiziologiya cheloveka, 1998, vol. 24, no. 1, pp. 16–20. 
  10. Kozhushko N.Yu. Informativnye priznaki elektroentsefalogrammy u detey s narusheniyami psikhicheskogo razvitiya perinatal’nogo geneza [Electroencephalography Informative Signs in Children with Psychic Development Disorders of Perinatal Genesis]. Vestnik Ivanovskoy meditsinskoy akademii, 2014, vol. 19, no. 4, pp. 36–40. 
  11. Kazantseva E.V. Techenie beremennosti, patogenez i profilaktika zaderzhki rosta ploda, obuslovlennoy neblagopriyatnym vliyaniem antropogennykh khimicheskikh veshchestv [Course of Pregnancy, Pathogenesis and Prevention of Fetal Growth Retardation Caused by Adverse Effects of Anthropogenic Chemicals]. Moscow, 2017. 227 p. 
  12. Tonkova-Yampol’skaya R.V. Sostoyanie zdorov’ya detey s uchetom faktorov ante- i postnatal’nogo riska [The State of Children’s Health Taking into Account Ante- and Postnatal Risk Factors]. Rossiyskiy pediatricheskiy zhurnal, 2002, no. 1, pp. 61–62. 
  13. Gorbachevskaya N.L., Davydova E.Yu., Petrova S.O., Tyushkevich S.A., Pashkevich O.I. The Importance of Biological and Social Factors for Academic Performance. Human Physiology, 2010, vol. 36, no. 3, pp. 66–73. 
  14. Grigor’eva L.P. Vliyanie faktorov deprivatsii na pertseptivno-kognitivnoe razvitie detey [Influence of Deprivation Effects on Perceptual/Cognitive Development in Children]. Vestnik MGLU, 2014, no. 16, pp. 305–311. 
  15. Koroleva N.V., Kolesnikov S.I., Dolgikh V.V. Korrelyatsionnye vzaimosvyazi mezhdu elektroentsefalograficheskimi pokazatelyami u detey v zavisimosti ot tipa elektroentsefalogrammy [Correlation Relationships Between Electroencephalographic Parameters in Children Depending on the Type of Electroencephalogram]. Ul’trazvukovaya i funktsional’naya diagnostika, 2001, no. 2, pp. 122–132. 
  16. Bezrukikh M.M., Farber D.A. Aktual’nye problemy fiziologii razvitiya rebenka [Current Issues of Child Developmental Physiology]. Novye issledovaniya, 2014, no. 3, pp. 4–19. 
  17. Machinskaya R.I., Krupskaya E.V. EEG-analiz funktsional’nogo sostoyaniya glubinnykh regulyatornykh struktur mozga u giperaktivnykh detey 7-8 let [EEG-Analysis of the Functional State of Deep Regulatory Structures of the Brain in Hyperactive Children Aged 7–8 Years]. Fiziologiya cheloveka, 2001, vol. 27, no. 3, pp. 122–124. 
  18. Kravtsov Yu.I., Koryukina I.P., Kalashnikova T.P. Klinicheskie i neyropsikhologicheskie proyavleniya dezadaptatsii u detey s otyagoshchennym perinatal’nym anamnezom [Clinical and Neuropsychological Manifestations of Maladaptation in Children with Burdened Perinatal History]. Rossiyskiy pediatricheskiy zhurnal, 2001, no. 4, pp. 14–17. 
  19. Koroleva N.V., Kolesnikov S.I., Dolgikh V.V. Bioelektricheskaya aktivnost’ golovnogo mozga u prakticheski zdorovykh detey-doshkol’nikov, perenesshikh perinatal’noe porazhenie TsNS [Brain Bioelectric Activity in Practically Healthy Preschool Children with Perinatal CNS Damage]. Rossiyskiy pediatricheskiy zhurnal, 2003, no. 6, pp. 15–20.