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Markers of Vascular Tone in the Blood of Elite Cross-Country Skiers of the Komi Republic During the Annual Training Cycle. P. 169–177

Версия для печати

Section: Physiology

UDC

612.127.4:796.92

DOI

10.17238/issn2542-1298.2019.7.2.169

Authors

Ol’ga I. Parshukova*, Evgeniy R. Boyko*, Vera E. Larina**
*Institute of Physiology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Komi SC UB RAS (Syktyvkar, Komi Republic, Russian Federation)
**Pitirim Sorokin Syktyvkar State University (Syktyvkar, Komi Republic, Russian Federation)
Corresponding author: Ol’ga Parshukova, address: ul. Pervomayskaya 50, Syktyvkar, 167982, Respublika Komi, Russian Federation; e-mail: olga-parshukova@mail.ru

Abstract

This study aimed to determine the levels of stable nitric oxide metabolites (nitrates and nitrites) in elite cross-country skiers during several annual training cycles and correlate these data with the athletes’ performance. The observation group included male skiers with the ranks of the Candidate for Master of Sport and Master of Sport that are members of the national team of the Komi Republic. The levels of nitrates and nitrites were assessed during the general (June–August), preparatory (September–October) and competitive (December–March) phases of the annual training cycle over three seasons (2012–2013, 2013–2014 and 2014–2015). In addition, the athletes’ race results were analysed and correlated with their blood levels of nitrates and nitrites at rest. We found that in 2012–2013 and 2013–2014, the skiers had lower levels of nitrate (p < 0.001 and p < 0.01, respectively) during the competitive period than during the general and preparatory periods. Compared to the previous seasons, 2014–2015 demonstrated the opposite dynamic. We revealed a positive correlation between the blood level of nitrites and the place taken in the competition (r = 0.5, p = 0.01) and a negative correlation between the content of nitrates (r = –0.4, p = 0.05) and the place taken. The results of this study indicate the importance of determining the levels of stable nitric oxide metabolites in the blood of elite athletes as one of the markers of working capacity and physical performance.

Keywords

elite cross-country skiers, stable nitric oxide metabolites, nitrates, nitrites, sport performance
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References

1. Golovachev A.I. Aktual’nye problemy rossiyskogo lyzhnogo sporta (materialy “Kruglogo stola”) [Actual Problems of Russian Ski Sports (Round Table)]. Vestnik sportivnoy nauki, 2010, no. 3, pp. 57–60.
2. Manukhina E.B., Malyshev I.Yu. Rol’ oksida azota v razvitii i preduprezhdenii disfunktsii endoteliya [The Role of Nitric Oxide in the Development and Prevention of Endothelial Dysfunction]. Vestnik VGMU, 2003, vol. 2, no. 2, pp. 5–17.
3. Bergholm R., Mäkimattila S., Valkonen M., Liu M.L., Lahdenperä S., Taskinen M.R., Sovijärvi A., Malmberg P., Yki-Järvinen H. Intense Physical Training Decreases Circulating Antioxidants and Endothelium-Dependent Vasodilation in vivo. Atherosclerosis, 1999, vol. 145, no. 2, pp. 341–349.
4. Andersson Hall U., Edin F., Pedersen A., Madsen K. Whole-Body Fat Oxidation Increases More by Prior Exercise Than Overnight Fasting in Elite Endurance Athletes. Appl. Physiol. Nutr. Metab., 2016, vol. 41, no. 4, pp. 430–437.
5. Aoi W., Naito Y., Takanami Y., Kawai Y., Sakuma K., Ichikawa H., Yoshida N., Yoshikawa T. Oxidative Stress and Delayed-Onset Muscle Damage After Exercise. Free Radic. Biol. Med., 2004, vol. 37, no. 4, pp. 480–487.
6. Rassaf T., Lauer T., Heiss C., Balzer J., Mangold S., Leyendecker T., Rottler J., Drexhage C., Meyer C., Kelm M. Nitric Oxide Synthase-Derived Plasma Nitrite Predicts Exercise Capacity. Br. J. Sports Med., 2007, vol. 41, no. 10, pp. 669–673.
7. Bogdanovskaya N.V., Malikov N.V. Rol’ sistemy sinteza oksida azota v obespechenii adaptatsii organizma k sistematicheskim fizicheskim nagruzkam [The Role of Nitric Oxide Synthesis System in Ensuring the Body’s Adaptation to Systematic Physical Loads]. Materialy VII Vserossiyskoy s mezhdunarodnym uchastiem shkoly-konferentsii po fiziologii myshts i myshechnoy deyatel’nosti “Novye podkhody k izucheniyu klassicheskikh problem” [Proceedings of the 7th Russia-Wide Conference on Muscle Physiology and Activity “New Approaches to Studying Classic Problems”]. Moscow, 2013, p. 89.
8. Shaposhnikova V.I., Barbarash N.A. Vysokaya rabotosposobnost’ i oksid azota [High Working Capacity and Nitrogen Monoxide]. Vestnik sportivnoy nauki, 2009, no. 6, pp. 39–43.
9. Schwellnus M.P. Olympic Textbook of Medicine in Sport. Oxford, 2008. 610 p. (Russ. ed.: Shvellnus M. Olimpiyskoe rukovodstvo po sportivnoy meditsine. Moscow, 2011. 672 p.).
10. Metel’skaya V.A., Gumanova N.G. Skrining-metod opredeleniya urovnya metabolitov oksida azota v syvorotke krovi [Screening as a Method for Determining the Serum Level of Nitric Oxide Metabolites]. Klinicheskaya laboratornaya diagnostika, 2005, no. 6, pp. 15–18.
11. Granger D.L., Taintor R.R., Boockvar K.S., Hibbs J.B. Jr. Measurement of Nitrate and Nitrite in Biological Samples Using Nitrate Reductase and Griess Reaction. Methods Enzymol., 1996, vol. 268, pp. 142–151.
12. Heitzer T., Krohn K., Albers S., Meinertz T. Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation by Increasing Nitric Oxide Activity in Patients with Type II Diabetes Mellitus. Diabetologia, 2000, vol. 43, no. 11, pp. 1435–1438.
13. Markov Kh.M. Oksid azota i serdechno-sosudistaya sistema [Ntirogen Oxide and the Cardio-Vascular System]. Uspekhi fiziologicheskikh nauk, 2001, vol. 32, no. 3, pp. 49–65.
14. Parakhonskiy A.P. Rol’ neyronal’noy NO-sintetazy v patologii serdtsa [The Role of Neuronal NO-Synthase in Heart Diseases]. Sovremennye naukoemkie tekhnologii, 2010, no. 9, p. 208.
15. Mazzone M., Carmeliet P. Drug Discovery: A Lifeline for Suffocating Tissues. Nature, 2008, vol. 453, no. 7199, pp. 1194–1195.
16. Gladwin M.T., Kim-Shapiro D.B. The Functional Nitrite Reductase Activity of the Heme-Globins. Blood, 2008, vol. 112, no. 7, pp. 2636–2647.
17. Khan S.A., Skaf M.N., Harrison R.W., Lee K., Minhas K.M., Kumar A., Fradley M., Shoukas A., Berkowitz D.E., Hare J.M. Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling: Independent Impact of Neuronal and Endothelial Nitric Oxide Synthases. Circ. Res., 2003, vol. 92, no. 12, pp. 1322–1329.
18. Layland J., Li J.-M., Shah A.M. Role of Cyclic GMP-Dependent Protein Kinase in the Contractile Response to Exogenous Nitric Oxide in Rat Cardiac Myocytes. J. Physiol., 2002, vol. 540, pt. 2, pp. 457–467.
19. Reutov V.P., Sorokina E.G., Kositsyn N.S., Okhotin V.E. Problema oksida azota v biologii i meditsine i printsip tsiklichnosti: retrospektivnyy analiz idey, printsipov i kontseptsiy [The Problem of Nitric Oxide in Biology and Medicine and the Principle of Cyclicity: A Retrospective Analysis of Ideas, Principles and Concepts]. Moscow, 2003. 96 p.
20. Godber B.L., Doel J.J., Sapkota G.P., Blake D.R., Stevens C.R., Eisenthal R., Harrison R. Reduction of Nitrite to Nitric Oxide Catalyzed by Xanthine Oxidoreductase. J. Biol. Chem., 2000, vol. 275, no. 11, pp. 7757–7763.



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