UDC

[[612.223.12:615.834]:612.127]-092.4

DOI

10.17238/issn2542-1298.2019.7.2.216

Authors

Viktor V. Zinchuk*, Elena S. Biletskaya*
*Grodno State Medical University (Grodno, Republic of Belarus)
Corresponding author: Viktor Zinchuk, address: ul. Gor’kogo 80, Grodno, 230009, Republic of Belarus; e-mail: zinchuk@grsmu.by

Abstract

The authors analysed their own and literature data on oxygen-dependent mechanisms of the physiological effects of ozone on the body. Administration of ozone activates metabolism, improves blood circulation and oxygen supply to ischemic tissues. Moreover, ozone can shift the oxidation-reduction equilibrium of metabolic systems, induce compensatory mobilization of endogenous antioxidants from the depot and activate the enzymatic unit of antiradical protection; these effects are aimed at stabilizing the dynamic equilibrium between free radical lipid oxidation and the body’s antioxidant processes. In addition, the effect of this physical factor on the oxygen transport function of the blood is discussed. Ozone changes the functional properties of haemoglobin, in particular, through hydrogen sulfide– cysteine–cystine pathway and NO-ergic mechanisms. The increase in the concentration of nitrogen monoxide in the blood is associated with ozone’s ability to activate factors facilitating the expression of NO synthase. The interaction of nitrogen monoxide with hydrogen sulfide can affect the modification of affinity of haemoglobin for oxygen through formation of various haemoglobin derivatives, modulation of the intra-erythrocyte system forming oxygen-binding properties of blood, as well as through systemic mechanisms forming functional properties of haemoglobin. The effect of ozone is manifested in an increase in the content of such gas transmitters as nitrogen monoxide and hydrogen sulfide, which influences the modification of oxygen-binding properties of blood. The antihypoxic action of ozone is realized with the participation of intra-erythrocyte gas-transmitting mechanisms, which justifies its application in medical practice. The established patterns specify the effects of ozone and can be used as a theoretical basis for developing new ways to improve the body’s adaptation mechanisms during hypoxia.

Keywords

ozone, blood, oxygen, gas transmitters

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