UDC

612.018+612.017+577.175

DOI

10.17238/issn2542-1298.2019.7.4.420

Authors

Ekaterina V. Nesterova* ORCID: 0000-0001-8467-2514
Fatima A. Bichkaeva* ORCID: 0000-0003-2970-4469
Ruslan A. Kochkin** ORCID:0000-0003-1844-0197
*N. Laverov Federal Center for Integrated Arctic Research, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
**Arctic Research Center (Salekhard, Yamalo-Nenets Autonomous Okrug, Russian Federation)
Corresponding author: Ekaterina Nesterova, address: prosp. Lomonosova 249, 163001, Arkhangelsk, Russian Federation; e-mail: Ekaterina29reg@mail.ru   

Abstract

As we know, the climate of high latitudes has a negative impact on the human body and leads to significant restructuring in its physiological systems. It has been established that the sympathoadrenal system plays a key role in adaptation to cold. This research involved 198 men and women aged 22–35, 36–45 and 46–60 years and living in the Yamalo-Nenets Autonomous Okrug (Nadym, Tolka, Krasnoselkup and Syoyakha). Catecholamines (adrenaline and norepinephrine) were determined in the urine by fluorimetric analysis. Multidirectional changes in the levels of adrenaline and norepinephrine depending on sex and age were revealed: in women the maximum level of the hormonal component of the sympathoadrenal system was noted at the age of 36–45 years, compared to other age groups, while in men at this age the level of adrenaline, on the contrary, had minimal values; the level of the mediator component of the sympathoadrenal system stayed within the physiological norm for both sexes. At the same time, 46–60-year-old men and women showed an increase in the activity of the mediator link of the sympathoadrenal system, compared to other age groups, with the maximum level of norepinephrine in 67 % of men and 45 % of women. To assess the balance between the hormonal and mediator components of the sympathoadrenal system, the ratio of norepinephrine excretion to adrenaline was determined. We found that in women aged 22–35 and 36–45 years, this ratio did not differ, while in women aged 46– 60 years, it was statistically significantly higher. Men aged 36–45 years showed statistically significantly low values of this ratio, compared to other age groups.

Keywords

catecholamines, sympathoadrenal system, men, women, Yamalo-Nenets Autonomous Okrug

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